Andrews’ group research focuses on understanding how serotonin neurotransmission encodes emotionally salient information related to anxiety, mood, and stress responsiveness. Serotonin transporter regulation of transmission is investigated in mouse models and neuropsychiatric patient populations. Neuropsychopharmacology, developmental timing, and stress are used to probe the serotonin system in the context of the etiology and treatment of anxiety and mood disorders, and predictive personalized medicine. Microelectrode voltammetry and microdialysis methods are developed to investigate serotonin transmission in vivo with high spatial and temporal resolution. Nanomaterials are designed for studies on neurotransmitter recognition by native and nonnative binding partners (aptamers) and for the development of field-effect transistor biosensors.
|Research Projects||Techniques used|
|Developmental influence of SERT on behavior||Fast cyclic voltammetry, in vivo microdialysis, chronoamperometry, Behavioral testing (elevated plus maze, open field, forced swim, social interaction, Lashley maze, sucrose consumption|
|SERT expression &function in peripheral blood cells: Prediction of antidepressant response||Chronoamperometry with boron-doped diamond electrodes, flow cytometry, RT-qPCR|
|Neurochip for in vivo nanobiosensing and proteomics||QCM, SPR, Fluorescence spectroscopy and microscopy, AFM, FT-IR and Ellipsometry|